![]() Although the primary mechanism of this action is inhibition of ovulation, other alterations include changes in the cervical mucus which increase the difficulty of sperm entry into the uterus, and changes in the endometrium which reduce the likelihood of implantation. Related/similar drugs norethindrone, levonorgestrel, medroxyprogesterone, Depo-Provera, Mirena, Sprintec Juleber - Clinical Pharmacology PharmacodynamicsĬombined oral contraceptives act by suppression of gonadotropins. Each "inactive" reminder white, biconvex, round tablets with "P" debossed on one side and " N" on the other side contains the following inactive ingredients: titanium dioxide, polydextrose, hypromellose, triacetin, polyethylene glycol, lactose, magnesium stearate, and pregelatinized corn starch. Juleber™ (desogestrel and ethinyl estradiol tablets, USP) provide an oral contraceptive regimen of 21 orange tablets each containing 0.15 mg desogestrel (13-ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol), and 0.03 mg ethinyl estradiol (19-nor-17 alpha-pregna-1,3,5 (10)-trien-20-yne-3,17, diol).Įach "active" orange tablet with "S3" debossed on one side contains the following inactive ingredients: lactose monohydrate, pregelatinized corn starch, povidone, stearic acid, vitaminE, HPMC/hypromellose, titanium dioxide, macrogol/polyethylene glycol, D&C Yellow #10 Aluminum Lake, FD&C Yellow #6 Aluminium Lake, Iron Oxide Yellow, FD&C Red #40 Aluminum Lake, FD&C Blue #2 Aluminum Lake. Patients should be counseled that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases. For this reason, combination oral contraceptives, including Juleber™, should not be used by women who are over 35 years of age and smoke. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. WARNING: CARDIOVASCULAR RISK ASSOCIATED WITH SMOKINGĬigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive use.
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